Although the main psychoactive chemical compound in Cannabis is Δ9-tetrahydrocannabinol (DELTA9 THC), the plant is known to contain about sixty cannabinoids; however, most of these "minor" cannabinoids are only produced in trace amounts.
Besides THC, another cannabinoid produced in high concentrations by some plants is cannabidiol (CBD), which is not psychoactive but has recently been shown to block the effect of THC in the nervous system.
Differences in the chemical composition of Cannabis varieties may produce different effects in humans. Synthetic THC, called dronabinol, does not contain CBD, CBN, or other cannabinoids, which is one reason why its pharmacological effects may differ significantly from those of natural Cannabis preparations.
Source: Wikipedia
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