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Showing posts with label cancer. Show all posts
Showing posts with label cancer. Show all posts

Saturday, September 4, 2010

People's Pharmacy: Medical marijuana shows promise in cancer cases

A reader asks whether cannabinoids can fight pancreatic tumor cells.
By Joe Graedon and Teresa Graedon, Ph.D.

Q: I would like you to know about medical marijuana for cancer. In her late 30s, my wife was diagnosed with pancreatic cancer, stage 4a. It was a 6-centimeter tumor that had grown around the hepatic artery and portal vein.

At first I thought marijuana was just for nausea caused by her chemo, but then I found a study in the journal Cancer Research (July 1, 2006). It showed that cannabinoids specifically fight pancreatic tumor cells.

I changed her diet and started her on a regimen, and she is now cancer-free. The regimen is being studied at the University of Wisconsin.

A: For years, marijuana research was suspected of being a way to rationalize people getting high. But as a recent article in Science News points out, scientists are now starting to take it seriously (June 19). The article you cite demonstrates that compounds from marijuana make pancreatic- tumor cells commit suicide.

Other cancer researchers have followed up with studies on its effectiveness against a range of tumors in test tubes, including breast, colon, glioblastoma brain tumors and lymphoma, a blood cancer. None is yet in a clinical trial, but this will be an interesting field to watch. We are delighted your wife had such a good response to such a difficult-to-treat cancer.

Q: I tried the soap-under-the-sheet remedy for leg cramps. It was successful, but it didn't last. Then my doctor prescribed Qualaquin 325-mg capsules, and they work like a charm.

This medication has quinine and is usually used for the treatment of malaria. Now I take one every other night, with excellent results.

A: The Food and Drug Administration has only approved Qualaquin (quinine) for the treatment of malaria. Any other use is considered "off label" and inappropriate. On July 8, the FDA issued the following warning: "Qualaquin should not be used for nighttime leg cramps."

The agency has received reports of serious blood reactions and kidney damage. In some cases, people have died from quinine toxicity.

Some readers have suggested that replacing the soap after several weeks might improve its effectiveness.

Q: What is the story about the toxic effects of zinc in denture creams?

A: Too much zinc, whether from dental adhesives or taken as a supplement, can lead to a copper deficiency. The possible consequences are anemia and neurological problems.

The New York Times Magazine described a 64-year-old woman who overused denture cream. Her balance was affected, along with the strength in her legs. Her doctors discovered that she had super-high levels of zinc and almost no copper in her bloodstream. They tracked the problem to the adhesive she used to keep her ill-fitting dentures in place.

GSK, maker of Super PoliGrip, has reformulated its denture-adhesive cream. The company urges consumers to look for the zinc-free product. The FDA is working with other manufacturers to reduce the risk that consumers might be exposed to excessive levels of zinc in their denture creams.

Source: The Seattle Times

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Thursday, July 22, 2010

NEWS: Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

ErbB2-positive breast cancer is characterized by highly aggressive phenotypes and reduced responsiveness to standard therapies. Although specific ErbB2-targeted therapies have been designed, only a small percentage of patients respond to these treatments and most of them eventually relapse.

The existence of this population of particularly aggressive and non-responding or relapsing patients urges the search for novel therapies. The purpose of this study was to determine whether cannabinoids might constitute a new therapeutic tool for the treatment of ErbB2-positive breast tumors.

We analyzed their antitumor potential in a well established and clinically relevant model of ErbB2-driven metastatic breast cancer: the MMTV-neu mouse. We also analyzed the expression of cannabinoid targets in a series of 87 human breast tumors.

Results: Our results show that both Delta9-tetrahydrocannabinol, the most abundant and potent cannabinoid in marijuana, and JWH-133, a non-psychotropic CB2 receptor-selective agonist, reduce tumor growth, tumor number, and the amount/severity of lung metastases in MMTV-neu mice.

Histological analyses of the tumors revealed that cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis, and impair tumor angiogenesis. Cannabinoid antitumoral action relies, at least partially, on the inhibition of the pro-tumorigenic Akt pathway.

We also found that 91% of ErbB2-positive tumors express the non-psychotropic cannabinoid receptor CB2.

Conclusions: Taken together, these results provide a strong preclinical evidence for the use of cannabinoid-based therapies for the management of ErbB2-positive breast cancer.

Author: Maria CaffarelClara AndradasEmilia MiraEduardo Perez-GomezCamilla CeruttiGema Moreno-BuenoJuana FloresIsabel Garcia-RealJose PalaciosSantos ManesManuel GuzmanCristina Sanchez
Credits/Source: Molecular Cancer 2010, 9:196

Source: 7th Space Interactive

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Thursday, February 11, 2010

NEWS: Screen actor Dennis Hopper has a doctor's letter that says his wife is endangering his life

Dennis Hopper's lawyer has filed legal papers in his divorce case stating that his estranged wife Victoria is endangering his life. The Screen actor is currently undergoing treatment for advanced prostate cancer.

He wants his wife to stay at least 15 yards away from him because he has a doctor's letter that states Victoria has repeatedly subjected Dennis to severe emotional distress and that the less he has to do with his wife the longer he will live.

The Doctor also says the actor (who uses medical marijuana) is in a sound state of mind and is able to make his own decisions. Dennis is demanding his wife move out of the family compound by March 11th and insists she return some of his art work.

Dennis filed for divorce in January. Victoria who has a six year old daughter, Galen, with Dennis thinks his adult children are manipulating him and encouraging him to cut her out of his will. The pre-nup states that Victoria will lose 25% of his estate if they divorce before his death.

Earlier legal papers also divulge that Dennis was very disturbed to hear Victoria's mother says he was going to die soon and that he should leave the bulk of his property to her daughter.

The couple have been legal wrangling over the amount of time that should go by between Dennis smoking pot and then seeing his young daughter. Victoria is insisting on six hours and Dennis thinks one hour is appropriate. Victoria is accusing Dennis of smoking weed in front of his daughter. Dennis is asking for daily visitation rights to his daughter from 5PM to 7 PM.

Source: Examiner

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TheCannabisChef.com - The Art and Science of Cooking with Cannabis (Medicinal Marijuana)